Regeneration of Vertebrate Appendages (Limbs and Fins)

  In adults, fish fins can regenerate completely by about 2 weeks after amputation. Previous work indicates that regenerative fin growth is greater after proximal amputation than after distal amputation (Lee et al, 2005). Therefore, we investigated levels of gene expression during such position-dependent regeneration by using quantitative PCR analyses.

We found that the position-dependent regeneration already occurred in the inflammatory period before the blastema proliferation period. We would like to find a candidate for factor during position-dependent regeneration and to understand similarities and differences of morphogenesis during development and regeneration.

Reference:

Lee Y, Grill S, Sanchez A, Murphy-Ryan M and Poss KD (2005) "Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration", Development 132, 5173-5183.