Archive
"ヒトの発生 Human Developmental Biology" Lecture
from April 2016- 2021 (2nd-year medical students) 90 min x1 per year
§ Limb Development (2016.12.14, 2017.11.22, 2018.11.21, 2019.11.11, 2020.11.9, 2021 (105 students))
Topics:# Limb Induction and Initiation (FGFs, HOX)
# Specification of Forelimb/Hindlimb (TBX)
# Proximal-Distal Axis (FGFs, RA, HOX, AER)
# Anterior-Posterior Axis (SHH, GLI3, ZPA)
# Dorsal-Ventral Axis
# Interdigits (Apoptosis, Turing pattern)
(# Bone and Joint Formation)
# Muscle/Tendon/Ligament Formation
# Nerves, Blood Vessels, Nails
# Genetic/Genomic Regulation (Enhancer, TAD, Malformation)
(# Limb Regeneration)
from April 2022- present (2nd-year medical students)
§ Embryogenesis (2023, 2024 (105 students))
Topics:
# Fertilization, Compaction, Implantation
# Epiblast, Hypoblast
# Placenta
# Gastrulation, Neurulation
# Organizer and Morphogen
§ Organogenesis (2023, 2024 (105 students))
Topics:
# Ectoderm, Mesoderm, Endoderm
# Somites and Muscles/Vertebra Formation
# Lateral/Intermediate Mesoderm
# Endoderm, Oral Cavity, Pharyngeal Arch
# Neural crest and Placode
# Sensory organs
§ Musculoskeletal Development (2022, 2023, 2024 (105 students))
Topics:# Proliferation, Differentiation, Deformation, Translocation in Embryogenesis and Growth
# Limb Induction and Initiation (FGFs)
# Limb Proximal-Distal Axis (FGFs, RA, HOX, AER, ZPA)
# Interdigits (Apoptosis, Turing pattern)
# Bone Modeling, Remodeling and Variations
# Developmental Origin and Comparative Morphology (Vertebra, Pharyngeal arch)
「脊椎動物形態学 (Vertebrate Morphology)」 講義
from January 2020- present (undergraduate students) 75 min x4 per year
§ Fish, Amphibian, Reptile Bird (and Mammal) (2020, 2021, 2022 (in English), 2023, 2024 (in English), 2025 (50~100 students))
Topics:# Homology
# Gnathostomes, Osteichthyes
# Limb Development
* Gastrulation and Germ Layers
* Proximal-Distal Axis (FGFs, AER, HOX)
* Evo-devo of Fin/Limb and Genetics, Paleontology
# Lung/Swim-bladder Development and Evolution
# Heart Development and Evolution
# Whole Genome Duplication
# Developmental constraint (Phylotypic stage, Organ modification)
* Pharyngeal Arches
* Gill/Parathyroid Evolution
# Amphibian and Amniotes (Chorion, Amnion)
# Axial Development and Evolution (Snake, Chick, Mouse)
# Limb positioning (HOX, TBX, GDF11)
# Digit number (Reptile/Birds, Cetartiodactyla/Perissodactyla)
* Anterior-Posterior Axis of Limb (SHH, GLI3, ZPA)
* Interdigital Formation (SOX9, BMP, Apoptosis, Turing pattern)
* Pentadactyl Constraint
# Heterochrony and Heterotopy
# Skin Appendages (Hair, Feather, Scales)
"Medical English" Exercise
from April 2015- 90 min x10 per year (The number of students to be admitted is 2-4.)
(3rd-year medical students: 2015, 4 students; 2016, 2 students; 2017, 5 students; 2018, 3 students; 2019, 2 students; 2021, 2 students; 2022, 2 students; 2024, 2 students)
Text: Regenerative Biology and Medicine, 2nd Edition
Author : David L. Stocum 2015, 2016, 2017, 2018
Release Date: 31 May 2012
Print Book ISBN : 9780123848604
Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine
store.elsevier.com/Regenerative-Biology-and-Medicine/David-Stocum/isbn-9780123848611/
Research articles #1: Seifert et al, Nature (2012) 2015, 2016, 2017"Skin shedding and tissue regeneration in African spiny mice (Acomys)"
www.nature.com/nature/journal/v489/n7417/full/nature11499.html
[Dr. Ashley W. Seifert Lab Website]
Research articles #2: Vaughan et al, Nature (2015) 2015
"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury"
www.nature.com/nature/journal/v517/n7536/abs/nature14112.html?lang=en
[Dr. Harold A. Chapman Lab Website]
Research articles #3: Zuo et al, Nature (2015) 2015
"p63+Krt5+ distal airway stem cells are essential for lung regeneration"
www.nature.com/nature/journal/v517/n7536/full/nature13903.html
Research articles #4: Snippert et al, Cell (2010) 2016, 2017, 2018
"Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells"
https://www.sciencedirect.com/science/article/pii/S0092867410010640
[Dr. Hans Clevers Lab Website]
https://doi.org/10.1038/nature22796
[Dr. Barbara Treutlein Lab Website]
Research articles #6: Liu et al, Cell (2018) 2019
"Rescue
of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene
"
https://doi.org/10.1016/j.cell.2018.01.012
[Dr. Rudolf Jaenisch Lab Website]
The Guardian content page, News and Views by Nature (2018), 腎臓再生医療
Report #12: Ushiki et al, Nature Communications (2021) 2022 "Deletion of CTCF sites in the SHH locus alters enhancer-promoter interactions and leads to acheiropodia" DOI [Dr. Nadav Ahituv Lab Website]
"Basic Laboratory Research" Exercise
from January 2014- present (6 weeks per year)
(3rd-year medical students: 2013, 1 student; 2014, 1 student; 2015, 1 student; 2016, 1 student; 2017, 2 students; 2018, 1 student; 2019, 1 student; 2021, 2 students; 2022, 1 student; 2023, 1 student)
(+, "Medical Research" Elective Program)
"Medical Research" Elective Program in Faculty of Medicine, and MD-PhD course in Graduate School of Medicine
〇 "Medical Research" Elective Program
# Aim: to educate medical students as basic medical scientists
# Activities: basic medical research in a laboratory after school
#Term: 1st - 6th year medical students (from anytime)
#Credits (to be acquired as graduation): 6 credits
Research article published as the first author, 6 credits; Oral/poster presentation in research meetings as a presenter, 2 credits;Research article published as a co-author, 2 credits; Oral/poster presentation in research meetings as a co-author, 1 credits (Student #2, 8 credits certificated (2014-2019); Student #4, 6 credits certificated (2016-2020); Student #7, 6 credits certificated (2018-2020))
〇 MD-PhD course
#Aim: to educate MD graduate students as PhD scientists
#Requirement: 6 credits of "Medical Research" Elective Program in Faculty of Medicine
#Term: 3 years
#Guarantee: school fees (3 years), scholarship (3 years), research grants (3 years)
解剖学講座（組織・発生）（岡部正隆研究室）への参画ルート（過去の例）
（学部生として）
1. 慈恵医大・医学部生として「ユニット医学研究」履修（1-6年次のいつからでも、任意期間。指導した学生へのインタビューはこちら、カリキュラム紹介はこちら）
2. 他学ラボ在籍者が研究実習生として慈恵医大へ派遣（短期の共同研究先として、あるいは他学制度次第では長期の研究教育委託先として）
（修士大学院生として）
3. 他学ラボ在籍者が研究実習生として慈恵医大へ派遣（短期の共同研究先として、あるいは他学制度次第では長期の研究教育委託先として）
（博士大学院生として）
4. 慈恵医大・博士課程に所属（入試あり） 募集要項
5. 他学ラボ在籍者が研究実習生として慈恵医大へ派遣（短期の共同研究先として、あるいは他学制度次第では長期の研究教育委託先として）
（研究員として）
6. 慈恵医大ポスドク制度に申請（大学全体で年2人公募審査あり。任期2年間。期間中に学振PDに移行など。）
7. 他学ラボ在籍者が訪問研究員として慈恵医大に所属（短期の共同研究先として）
Journal Club
Research papers I have been interested in and introduced in our lab are...
2019.11.22
"Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish"
Xie et al, from Dr. Andrei Chagin Lab
https://doi.org/10.1073/pnas.1900038116
2019.5.16
"MicroRNA-dependent regulation of biomechanical genes establishes tissue
stiffness homeostasis"
Moro
et al, from Dr. Stefania Nicoli Lab
https://doi.org/10.1038/s41556-019-0272-y
2018.5.24
"Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock"
Lleras-Forero et al, from Dr. Stefan Schulte-Merker Lab
https://doi.org/10.7554/eLife.33843
2017.6.22
"The extracellular matrix protein Agrin promotes heart regeneration in mice"
Bassat et al, from Dr. Eldad Tzahor Lab
https://dx.doi.org/10.1038/nature22978
2016.9.16
"A somitic contribution to the apical ectodermal ridge is essential for fin formation"
Masselink et al, from Dr. Peter D. Currie Lab
https://dx.doi.org/10.1038/nature18953
"Digits and fin rays share common developmental histories"
Nakamura et al, from Dr. Neil H. Shubin Lab
https://dx.doi.org/10.1038/nature19322
2015.11.27
"Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway"
Voutilainen et al, from Dr. Marja L. Mikkola Lab
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005676
2015.5.7
"On the development of the patella"
Eyal et al, from Dr. Elazar Zelzer Lab
dev.biologists.org/content/142/10/1831.abstract
2014. 9
"A dynamic analysis of muscle fusion in the chick embryo"
Sieiro-Mosti et al, from Dr. Christophe Marcelle Lab
dev.biologists.org/content/141/18/3605.abstract
2013
"Sept4/ARTS regulates stem cell apoptosis and skin regeneration"
Fuchs et al, from Dr. Hermann Steller Lab
https://www.sciencemag.org/content/341/6143/286.abstract
"Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons"
Lacombe et al, from Dr. Jeremy S. Dasen Lab
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003184
"Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity"
Unhavaithaya and Orr-Weaver, from Dr. Terry L. Orr-Weaver Lab
https://genesdev.cshlp.org/content/26/1/31.abstract
"Self-organized shuttling: generating sharp dorsoventral polarity in the early Drosophila embryo"
Haskel-Ittah et al, from Dr. Naama Barkai Lab
https://www.sciencedirect.com/science/article/pii/S0092867412009270
2011
"Cryptic patterning of avian skin confers a developmental facility for loss of neck feathering"
Mou et al, from Dr. Denis J. Headon Lab
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001028
2010
"Coupling of apoptosis and L/R patterning controls stepwise organ looping"
Suzanne et al, from Dr. Stéphane Noselli Lab
https://www.sciencedirect.com/science/article/pii/S096098221001078X
"Generation of a novel wing colour pattern by the Wingless morphogen"
Werner et al, from Dr. Sean B. Carroll Lab
https://www.nature.com/nature/journal/v464/n7292/full/nature08896.html
2009
"The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity"
Fauny et al, from Dr. Christine Thisse Lab
https://doi.org/10.1242/dev.039693
"Uncoupling Time and Space in the Collinear Regulation of Hox Genes"
Tschopp et al, from Dr. Denis Duboule Lab
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000398
"Observations on continuously growing roots of the sloth and the K14-Eda transgenic mice indicate that epithelial stem cells can give rise to both the ameloblast and root epithelium cell lineage creating distinct tooth patterns"
Tummers and Thesleff from Dr. Irma Thesleff Lab
"Development of the dermal skeleton in Alligator mississippiensis (Archosauria, Crocodylia) with comments on the homology of osteoderms"
Vickaryous and Hall, from Dr. Brian K. Hall Lab
https://doi.org/10.1002/jmor.10575
2007 ...not remember
2006 ...not remember